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GENOMICS AND BIOINFORMATICS GRAZ
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BIOINFORMATICS [444.137, 2VO WS] [444.138, 2UE WS] [MOL.969, 2VO WS] [MOL.970, 2UE WS]

LECTURER EXERCISES
Gerhard Thallinger Bettina Halwachs, Wolfgang Kopp


DESCRIPTION

Introduction, genetics, internet, biological databases, GenBank sequence database, structure databases, sequence analysis, information retrieval from biological databases, sequence alignment and database searching, phylogenetic analysis, predictive methods using protein sequences, navigating public physical mapping databases.


TEXTBOOKS

Computational Methods in Molecular Biology. Salzberg SL, Searl S, Kasif S (eds). Elsevier, Amsterdam, NL, 1999 (Chapter 1-4) [pdf]

Bioinformatics: A practical Guide to the Analysis of Genes and Proteins. Baxevanis AD, Ouellette BF (eds). John Wiley & Sons, New York, 1998 (Chapter 1-5) [pdf]


DOCUMENTS

Introduction [pdf] Dayhoff - A Model of Evolutionary Change in Proteins[pdf]
Lecture Notes [pdf] Schwartz - Matrices for Detecting Distant Relationships [pdf]
List of questions [pdf] Henikoff - Amino acid substitution matrices from protein blocks [pdf]
Eddy - Where did the BLOSUM62 alignment score matrix come from? [pdf]
Nyakatura - Next Generation Sequencing [pdf]
Metzker - Sequencing technologies [pdf]
Glenn - Field Guide to DNA Sequencing [pdf] Rothberg - An integrated semiconductor device enabling non-optical... [pdf]