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BIOINFORMATICS [444.137, 2VO WS] [444.138, 2UE WS] [MOL.969, 2VO WS] [MOL.970, 2UE WS]

Gerhard Thallinger Bettina Halwachs, Wolfgang Kopp


Introduction, genetics, internet, biological databases, GenBank sequence database, structure databases, sequence analysis, information retrieval from biological databases, sequence alignment and database searching, phylogenetic analysis, predictive methods using protein sequences, navigating public physical mapping databases.


Computational Methods in Molecular Biology. Salzberg SL, Searl S, Kasif S (eds). Elsevier, Amsterdam, NL, 1999 (Chapter 1-4) [pdf]

Bioinformatics: A practical Guide to the Analysis of Genes and Proteins. Baxevanis AD, Ouellette BF (eds). John Wiley & Sons, New York, 1998 (Chapter 1-5) [pdf]


Introduction [pdf] Dayhoff - A Model of Evolutionary Change in Proteins[pdf]
Lecture Notes [pdf] Schwartz - Matrices for Detecting Distant Relationships [pdf]
List of questions [pdf] Henikoff - Amino acid substitution matrices from protein blocks [pdf]
Eddy - Where did the BLOSUM62 alignment score matrix come from? [pdf]
Nyakatura - Next Generation Sequencing [pdf]
Metzker - Sequencing technologies [pdf]
Glenn - Field Guide to DNA Sequencing [pdf] Rothberg - An integrated semiconductor device enabling non-optical... [pdf] Margulies - Genome sequencing in microfabricated high-density ... [pdf] Bentley - Accurate whole human genome sequencing using ... [pdf] Shendure - Accurate Multiplex Polony Sequencing of an Evolved ... [pdf] Mardis - Next-Generation DNA Sequencing Methods [pdf] Eid - Real-Time DNA Sequencing from Single Polymerase Molecules [pdf] Clarke - Continuous base identification for single-molecule nanopore ... [pdf]


Illumina Sequencing [mp4]
Ion Torrent Chemistry [mp4]
Nanopore DNA Sequencing [mp4]
Pyro Sequencing [mp4]
Single Molecule Real Time Sequencing [mp4]